Pathology

Pathology is a branch of medical science primarily concerning the cause, origin, and nature of disease. It involves the examination of tissues, organs, bodily fluids, and autopsies in order to study and diagnose disease.

Currently, pathology can be divided into eight main areas, depending on the types of methods used or the types of diseases examined. These different disciplines are described below.

General pathology


General pathology describes a complex and broad field that involves the study of the mechanisms behind cell and tissue injury and understanding how the body responds to and repairs injury. Examples of areas that may be studied include necrosis, neoplasia, wound healing, inflammation and how cells adapt to injury. Thorough understanding in these areas is applied in the diagnosis of disease. General pathology is also the term used to describe anatomical and clinical pathology.

This field covers areas of pathology, but at a less specialist level. A person working in general pathology would be trained in the areas of laboratory analysis, such as hematology and clinical chemistry. However, they would have a less detailed knowledge than a person who specializes in one of these fields.

Anatomical pathology


This field is concerned with the study and diagnosis of illness through microscopic analysis of samples from bodily fluids, tissues organs and sometimes the entire body or autopsy. Factors that may be examined include the cell appearance, anatomical makeup and chemical signatures within cells.

This discipline can be subdivided into several disciplines and examples of these are given below:

  • Histology – Samples of bodily tissues and organs are prepared and examined in order to detect and diagnose disease. The architecture of tissue is observed at a microscopic level and the relationship between different cell and tissue types is examined.
  • Cytology – Bodily fluids and tissues are examined at the cellular level in order to screen for and diagnose disease and help aid treatment decisions. A cytologist will examine how cells look, form and function.
  • Forensic pathology – Forensic pathology is the examination of an autopsy in order to discover the cause of death. The external appearance is first assessed to check for evidence of wounds or suffocation, for example. Surgical procedures are then begun and the internal organs are studied to see whether internal injuries exist and are connected to external ones.

Clinical pathology


Also referred to as laboratory medicine, clinical pathology concerns the analysis of blood, urine and tissue samples to examine and diagnose disease. Examples of the information clinical pathology laboratories may provide include blood count, blood clotting and electrolyte results. A clinical pathologist is usually trained in microbiology, hematology or blood banking, but not at the same expert level as someone who specializes in one of these fields.

A clinical pathologist may come across problems that demand specific expertise, at which point they would need to consult a more specialized colleague. Clinical pathologists play a similar role to that of general pathologists, although they would not be involved in anatomical pathology.

Chemical Pathology or Biochemistry


Biochemists or chemical pathologists examine all aspects of disease, identifying changes in various different substances found in the blood and bodily fluids such as proteins, hormones and electrolytes since these changes can indicate and provide clues about disease or disease risk.

For example, a biochemist may assess cholesterol and triglyceride levels in order to determine heart disease risk. They may also look for and measure tumor markers, vitamins, poisons, medications and recreational drugs.

Genetics


There are three main branches of genetics and these include the following:

  • Cytogenetics: This is the analysis of chromosomal abnormalities at the microscopic level.
  • Biochemical genetics: The search for specific disease markers using biochemical techniques.
  • Molecular genetics: Gene mutations are searched for and analyzed using DNA technology.

Genetics involves performing tests on chromosomes, biochemical markers and DNA taken from bodily fluids and tissues in order to detect genetic illnesses.

Hematology


This field is concerned with various different disease aspects that affect the blood, including bleeding disorders, clotting problems, and anemia, for example. Another area of hematology is transfusion medicine, which involves performing blood typing, cross-matching for compatibility and managing large amounts of blood products. An example of a test a hematologist may perform is a blood clotting test to check whether a patient’s dose of warfarin needs increasing or decreasing.

Immunology


Immunologists perform immune function tests to establish whether or not a patient is suffering from an allergy and if so, what they are allergic to. Many diseases also arise as a result of the immune system having an abnormal reaction to healthy cells or tissues and launching an immune attack against them. This is referred to as a autoimmune disease. There is a range of immunological tests that can detect markers of autoimmune diseases such as rheumatoid arthritis, diabetes and lupus.

Microbiology


Microbiology is concerned with diseases caused by pathogenic agents such as bacteria, viruses, parasites and fungi. Samples of blood, bodily fluid and tissue are tested to establish whether infection exists, and the field of medical microbiology is also engaged with identifying new species of microorganisms.

Other areas encompassed by microbiology include control of infection outbreaks and researching the problems resulting from bacterial antibiotic resistance. One of the principal roles of the microbiologist is to make sure that antimicrobial drugs are prescribed and used appropriately.

Anaesthesia

Anesthesia is a treatment using drugs called anesthetics. These drugs keep you from feeling pain during medical procedures. Anesthesiologists are medical doctors who administer anesthesia and manage pain. Some anesthesia numbs a small area of the body. General anesthesia makes you unconscious (asleep) during invasive surgical procedures.

What is anesthesia?


Anesthesia is a medical treatment that keeps you from feeling pain during procedures or surgery. The medications used to block pain are called anesthetics. Different types of anesthesia work in different ways. Some anesthetic medications numb certain parts of the body, while other medications numb the brain, to induce a sleep through more invasive surgical procedures, like those within the head, chest, or abdomen.

How does anesthesia work?


Anesthesia temporarily blocks sensory/pain signals from nerves to the centers in the brain. Your peripheral nerves connect the spinal cord to the rest of your body.

Who performs anesthesia?


If you’re having a relatively simple procedure like a tooth extraction that requires numbing a small area, the person performing your procedure can administer the local anesthetic. For more complex and invasive procedures, your anesthetic will be administered by a physician anesthesiologist. This medical doctor manages your pain before, during and after surgery. In addition to your physician anesthesiologist, your anesthesia team can be comprised of physicians in training (fellows or residents), a certified registered nurse anesthetist (CRNA), or a certified anesthesiologist assistant (CAA).

What are the types of anesthesia?


The anesthesia your healthcare provider uses depends on the type and scope of the procedure. Options include:

  • Local anesthesia: This treatment numbs a small section of the body. Examples of procedures in which local anesthesia could be used include cataract surgery, a dental procedure or skin biopsy. You’re awake during the procedure.
  • Regional anesthesia: Regional anesthesia blocks pain in a larger part of your body, such as a limb or everything below your chest. You are can be conscious during the procedure, or have sedation in addition to the regional anesthetic. Examples include an epidural to ease the pain of childbirth or during a cesarean section (C-section), a spinal for hip or knee surgery, or an arm block for hand surgery.
  • General anesthesia: This treatment makes you unconscious and insensitive to pain or other stimuli. General anesthesia is used for more invasive surgical procedures, or procedures of the head, chest, or abdomen.
  • Sedation: Sedation relaxes you to the point where you will have a more natural sleep, but can be easily aroused or awakened. Light sedation can be prescribed by the person performing your procedure, or together with a regular nurse, if they both have training to provide moderate sedation. Examples of procedures performed with light or moderate sedation include cardiac catheterization and some colonoscopies. Deep sedation is provided by an anesthesia professional because your breathing may be affected with the stronger anesthetic medications, but you will be more asleep than with light or moderate sedation. Although you won’t be completely unconscious, you are not as likely to remember the procedure.

How should I prepare for anesthesia?


Make sure your healthcare provider has a current list of the medications and supplements (vitamins and herbal medications) you take. Certain drugs can interact with anesthesia or cause bleeding and increase the risk of complications. You should also:

  • Avoid food and drinks for eight hours before you go to the hospital unless directed otherwise.
  • Quit smoking, even if it’s just for one day before the procedure, to improve heart and lung health. The most beneficial effects are seen with no smoking for two weeks before.
  • Stop taking herbal supplements for one to two weeks before the procedure as directed by your provider.
  • Not take Viagra® or other medications for erectile dysfunction at least 24 hours before the procedure.
  • You should take certain (but not all) blood pressure medications with a sip of water as instructed by your healthcare provider.

What happens during anesthesia?


A physician anesthesiologist:

  • Administers one type or a combination of anesthetics listed above pain therapies, and possibly anti-nausea medications.
  • Monitors vital signs, including blood pressure, blood oxygen level, pulse and heart rate.
  • Identifies and manages problems, such as an allergic reaction or a change in vital signs.
  • Provides postsurgical pain management.

What should I do after getting anesthesia?


For procedures using local anesthesia, you can return to work or most activities after treatment unless your healthcare provider says otherwise. You’ll need more time to recover if you’ve received regional or general anesthesia or sedation. You should:

  • Have someone drive you home.
  • Rest for the remainder of the day.
  • Not drive or operate equipment for 24 hours.
  • Abstain from alcohol for 24 hours.
  • Only take medications or supplements approved by your provider.
  • Avoid making any important or legal decisions for 24 hours.

How long does it take to recover from anesthesia?


Anesthetic drugs can stay in your system for up to 24 hours. If you’ve had sedation or regional or general anesthesia, you shouldn’t return to work or drive until the drugs have left your body. After local anesthesia, you should be able to resume normal activities, as long as your healthcare provider says it’s okay.

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Laryngoscopy

A laryngoscopy is an examination that gives your doctor a close-up view of your larynx and throat. The larynx is your voice box. It’s located at the top of your windpipe, or trachea.

It’s important to keep your larynx healthy because it contains your vocal folds, or cords. Air passing through your larynx and over the vocal folds causes them to vibrate and produce sound. This gives you the ability to speak.

A specialist known as an “ear, nose, and throat” (ENT) doctor will perform the exam. During the exam, your doctor place a small mirror into your throat, or insert a viewing instrument called a laryngoscope into your mouth. Sometimes, they’ll do both.

A laryngoscopy is a procedure healthcare providers use to examine your larynx (voice box). This is performed with a laryngoscope, a thin tube with a light, lens and a video camera that helps providers look closely at your larynx. Providers may do laryngoscopies in a clinic office or as surgery in an operating room.

What is my larynx?


Your larynx is located between your throat and your trachea (windpipe). Your larynx houses your vocal cords (vocal folds), which enable you to speak and sing. Your epiglottis sits on top of your larynx. Your epiglottis is a flap that closes when you eat or drink so items intended for your esophagus (food pipe) don’t end up in your larynx or in your airway. When people talk about something going down the wrong pipe, the pipe they’re talking about is your larynx.

When is laryngoscopy needed?


Your doctor may do it to find out why you have a sore throat that won’t go away or to diagnose an ongoing problem such as coughing, hoarseness, or bad breath. They also might do one when:

  • You have something stuck in your throat.
  • You have trouble breathing or swallowing.
  • You have an earache that won’t go away.
  • They need to examine something that could be a sign of a more serious health problem such as cancer.
  • They need to remove a growth.

Types of laryngoscopy


There are several ways your doctor may do this procedure:

Indirect laryngoscopy: This is the simplest form. Your doctor uses a small mirror and a light to look into your throat. The mirror is on a long handle, like the kind a dentist often uses, and it’s placed against the roof of your mouth.

The doctor shines a light into your mouth to see the image in the mirror. It can be done in a doctor’s office in just 5 to 10 minutes.

You’ll sit in a chair while the exam is done. Your doctor might spray something into your throat to make it numb. Having something stuck in your throat might make you gag, however.

Direct fiber-optic laryngoscopy: Many doctors now do this kind, sometimes called flexible laryngoscopy. They use a small telescope at the end of a cable, which goes up your nose and down into your throat.

It takes less than 10 minutes. You’ll get a numbing medication for your nose. Sometimes a decongestant is used to open your nasal passages as well. Gagging is a common reaction with this procedure as well.

Direct laryngoscopy: This is the most involved type. Your doctor uses a laryngoscope to push down your tongue and lift up the epiglottis. That’s the flap of cartilage that covers your windpipe. It opens during breathing and closes during swallowing.

Your doctor can do this to remove small growths or samples of tissue for testing. They can also use this procedure to insert a tube into the windpipe to help someone breathe during an emergency or in surgery.

Direct laryngoscopy can take up to 45 minutes. You’ll be given what’s called general anesthesia, so that you will not be awake during the procedure. Your doctor can take out any growths in your throat or take a sample of something that might need to be checked more closely.

I’m having a laryngoscopy what should I expect?


Your healthcare provider will consider your specific situation when deciding which type of laryngoscopy they’ll use. You may have your laryngoscopy in a clinic office or as a surgical procedure. For example, your provider may decide you should have a surgical laryngoscopy in an operating room. This is a direct laryngoscopy. Providers typically do direct laryngoscopies following in-office flexible laryngoscopies. Direct laryngoscopies may be done along with biopsies or other surgical procedures.

What happens before laryngoscopy?


If you’re having a surgical laryngoscopy, you’ll receive general anesthesia. Your provider will talk to you about getting ready for your procedure:

  • You may need to fast the night before your procedure.
  • You may need to avoid certain medications before your procedure.
  • If you smoke, your provider may recommend you stop smoking a week or so before your procedure.
  • You’ll need someone to give you a ride home after your surgery.

What happens during laryngoscopy?


Surgical laryngoscopies and clinic office laryngoscopies have different processes.

Laryngoscopy in an office clinic

  • In some cases, your provider may use a small, tilted mirror and a bright light to examine your vocal cords.
  • They also may use a flexible laryngoscope. This is a flexible fiberoptic scope inserted through your nose to look down your throat.
  • Your provider will apply a small amount of numbing medicine and decongestant to your nose. The numbing medication may taste bitter.
  • You may feel an urge to cough, but that urge is likely to subside.
  • Your provider will then gently pass the flexible laryngoscope into a nostril and look down your throat.
  • They may have you speak during the test to see how your voice box is working.
  • In some circumstances, they may use a special scope that’s inserted through your mouth.

Direct laryngoscopy in the operating room

Your provider will use a special laryngoscope that’s inserted through your mouth. Because you had general anesthesia, you won’t feel anything.

What happens after laryngoscopy?


Different things happen depending on whether you had a surgical laryngoscopy or one done in an office clinic.

In-office clinic laryngoscopy

  • Your nose and throat may feel numb for a few minutes after the procedure. This usually wears off in about 20 minutes.
  • You should avoid eating or drinking while your mouth and throat are numb.

Operating room direct laryngoscopy

  • You’ll go to the recovery unit after surgery to recover from anesthesia so your provider can watch for any complications or problems.
  • You may have a mild sore throat and/or hoarseness. Your provider may want you to rest your voice for a while after your surgery.

What are the benefits of a laryngoscopy?


Your doctor is concerned that you may have a problem in your larynx. A laryngoscopy is a good way of finding out if there is a problem.

If your surgeon finds a problem, they can perform biopsies (removing small pieces of tissue) to help make the diagnosis. For some people, the treatment can be performed at the same time.

For some people minor treatments can be performed at the same time.

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Functional Endoscopic Sinus Surgery

Functional endoscopic sinus surgery (FESS) is a minimally invasive procedure which uses nasal endoscopes to enlarge the nasal drainage pathways of the paranasal sinuses to improve sinus ventilation and allow access of topical medications. This procedure is generally used to treat inflammatory and infectious sinus diseases, including chronic rhino sinusitis that do not respond to drugs, nasal polyps, some cancers, and decompression of eye sockets/optic nerve in Graves ophthalmopathy. In the surgery, an otolaryngologist removes the uncinate process of the ethmoid bone, while visualizing the nasal passage using a fiber optic endoscope. FESS can be performed under local anesthesia as an outpatient procedure. Generally patients experience only minimal discomfort during and after surgery. The procedure can take from 2 to 4 hours to complete.

Medical applications


Functional endoscopic sinus surgery is most commonly used to treat chronic rhinosinusitis (CRS), only after all non-surgical treatment options such as antibiotics, topical nasal corticosteroids, and nasal lavage with saline solutions[3] have been exhausted. (CRS) is an inflammatory condition in which the nose and at least one sinus become swollen and interfere with mucus drainage It can be caused by anatomical factors such as a deviated septum or nasal polyps (growths), as well as infection. Symptoms include difficulty breathing through the nose, swelling and pain around the nose and eyes, postnasal drainage down the throat, and difficulty sleeping. CRS is a common condition in children and young adults.

The purpose of FESS in treatment of CRS is to remove any anatomical obstructions that prevent proper mucosal drainage. A standard FESS includes removal of the uncinate process, and opening of the ethmoid air cells and Haller cells as well as the maxillary ostium, if necessary. If any nasal polyps obstructing ventilation or drainage are present, they are also removed. In the case of paranasal sinus/nasal cavity tumors (benign or cancerous), an otolaryngologist can perform FESS to remove the growths, sometimes with the help of a neurosurgeon, depending on the extent of the tumor. In some cases, a graft of bone or skin is placed by FESS to repair damages by the tumor.

In the thyroid disorder known as Graves’ ophthalmopathy, inflammation and fat accumulation in the orbitonasal region cause severe proptosis. In cases that have not responded to corticosteroid treatment, FESS can be used to decompress the orbital region by removing the ethmoid air cells and lamina papyracea. Bones of the orbital cavity or portions of the orbital floor may also be removed. endoscopic approach to FESS is a less invasive method than open sinus surgery, which allows patients to be more comfortable during and after the procedure. Entering the surgical field via the nose, rather than through an incision in the mouth as in the previous Caldwell-Luc method, decreases risk of damaging nerves which innervate the teeth. Because of its less-invasive nature, FESS is a common option for children with CRS or other sinonasal complications.

It has been suggested that one of the main objectives in FESS surgery is to allow for the introduction of local therapeutic agents (such as steroids) to the sinuses. Research has shown that a special modification of the nozzle of the nasal spray in patients who had FESS allows for better delivery of local therapeutic agents into the ethmoid sinuses.

What is the difference between ESS and FESS?


ESS or Endoscopic Sinus Surgery is a broader term which covers any endoscopic surgery of the nose and sinuses, including FESS. ESS may not be functional (e.g preservation of mucosa) and some indications for ESS include resection of sinonasal tumour, resection of skull base or brain tumour through the nose and sinuses, surgery of the eye through the nose and sinuses and surgery on the nasal septum.

Why do people call it functional endoscopic sinus surgery?


Functional endoscopic sinus surgery is also called endoscopic sinus surgery. Some healthcare providers use the term “functional” because the surgery is done to restore how your sinuses work, or function.

When would I need functional endoscopic sinus surgery?


Your healthcare provider may recommend FESS if you have chronic sinus inflammation or a chronic sinus infection that doesn’t improve with medical treatments, such as antibiotics and medications to manage allergies.

You develop sinusitis when the tissue that lines your sinuses begins to swell, trapping mucus that typically flows through your sinuses and out through your nose. The trapped fluid can grow bacteria that can cause infections. Healthcare providers may also recommend surgery if you have nasal polyps.

What happens before this procedure?


Your healthcare provider will let you know what to do before your surgery. Every person’s situation is different, but most healthcare providers recommend the following:

  • If you smoke, stop smoking at least three weeks before your surgery. Smoking can make your sinus symptoms worse. Ask your healthcare provider for advice or resources to help with this.
  • Don’t take aspirin for at least 10 days before your surgery. Even small amounts of aspirin can increase how much you bleed during and after your surgery.
  • If your surgery involves general anesthesia, don’t eat or drink anything after midnight the day of your surgery.
  • Your healthcare provider will administer general anesthesia just before your surgery begins.

How is functional endoscopic surgery performed?


FESS is the standard procedure to treat serious sinus conditions. Healthcare providers continue to refine their approach. Here’s an overview of the process:

  • Your healthcare provider puts decongestant medication in your nose.
  • They do a follow-up nasal endoscopy.
  • They inject a numbing solution into your nose.
  • Using the endoscope, they gently enter your nose. They insert surgical tools alongside the endoscope to use the endoscope to remove bone, diseased tissue or polyps that may be blocking your sinuses.
  • They may also use a small rotating burr to scrape out tissue.
  • Finally, your healthcare provider may pack your nose with material to absorb any blood or discharge.

What is the recovery after FESS?


After sinus surgery, the surgeon will usually place dressings in the sinus cavities to prevent post-operative adhesions and to minimise bleeding. These dressings may be absorbable (which do not require removal) or non-absorbable (which will usually be removed between 5 – 10 days after surgery). In some conditions, “nasal packs” may be inserted in the nasal cavities to minimise bleeding after surgery. These “nasal packs” are non absorbable and are usually removed in 1 – 2 days. Depending on the extent of the sinus operation, the patient may be allowed to go home on the same day (as a Day Surgery Procedure) or may be admitted to the ward and observed overnight. It is common for patients to feel blocked in the nose from the packing material and blood clots. A nasal gauze (“bolster”) will be placed under the nose to collect any blood that drips out (Fig 2). This is usually removed before the patient goes home. There may be mild pain after the surgery but this is usually well-controlled with pain relievers.

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What Is Cancer?

Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts of the body.Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Normally, human cells grow and multiply (through a process called cell division) to form new cells as the body needs them. When cells grow old or become damaged, they die, and new cells take their place.Sometimes this orderly process breaks down, and abnormal or damaged cells grow and multiply when they shouldn’t. These cells may form tumors, which are lumps of tissue. Tumors can be cancerous or not cancerous (benign).

Cancerous tumors spread into, or invade, nearby tissues and can travel to distant places in the body to form new tumors (a process called metastasis). Cancerous tumors may also be called malignant tumors. Many cancers form solid tumors, but cancers of the blood, such as leukemias, generally do not.

Benign tumors do not spread into, or invade, nearby tissues. When removed, benign tumors usually don’t grow back, whereas cancerous tumors sometimes do. Benign tumors can sometimes be quite large, however. Some can cause serious symptoms or be life threatening, such as benign tumors in the brain.

Differences between Cancer Cells and Normal Cells


Cancer cells differ from normal cells in many ways. For instance, cancer cells:

  • grow in the absence of signals telling them to grow. Normal cells only grow when they receive such signals.
  • ignore signals that normally tell cells to stop dividing or to die (a process known as programmed cell death, or apoptosis).
  • invade into nearby areas and spread to other areas of the body. Normal cells stop growing when they encounter other cells, and most normal cells do not move around the body.
  • tell blood vessels to grow toward tumors.  These blood vessels supply tumors with oxygen and nutrients and remove waste products from tumors.
  • hide from the immune system. The immune system normally eliminates damaged or abnormal cells.
  • trick the immune system into helping cancer cells stay alive and grow. For instance, some cancer cells convince immune cells to protect the tumor instead of attacking it.
  • accumulate multiple changes in their chromosomes, such as duplications and deletions of chromosome parts. Some cancer cells have double the normal number of chromosomes.
  • rely on different kinds of nutrients than normal cells. In addition, some cancer cells make energy from nutrients in a different way than most normal cells. This lets cancer cells grow more quickly.

Many times, cancer cells rely so heavily on these abnormal behaviors that they can’t survive without them. Researchers have taken advantage of this fact, developing therapies that target the abnormal features of cancer cells. For example, some cancer therapies prevent blood vessels from growing toward tumors, essentially starving the tumor of needed nutrients.

How Does Cancer Develop?


Cancer is a genetic disease—that is, it is caused by changes to genes that control the way our cells function, especially how they grow and divide.

Genetic changes that cause cancer can happen because:

  • of errors that occur as cells divide.
  • of damage to DNA caused by harmful substances in the environment, such as the chemicals in tobacco smoke and ultraviolet rays from the sun.
  • they were inherited from our parents.

The body normally eliminates cells with damaged DNA before they turn cancerous. But the body’s ability to do so goes down as we age. This is part of the reason why there is a higher risk of cancer later in life.

Each person’s cancer has a unique combination of genetic changes. As the cancer continues to grow, additional changes will occur. Even within the same tumor, different cells may have different genetic changes.

 

Types of Genes that Cause Cancer


The genetic changes that contribute to cancer tend to affect three main types of genes—proto-oncogenes, tumor suppressor genes, and DNA repair genes. These changes are sometimes called “drivers” of cancer.

Proto-oncogenes are involved in normal cell growth and division. However, when these genes are altered in certain ways or are more active than normal, they may become cancer-causing genes (or oncogenes), allowing cells to grow and survive when they should not.

Tumor suppressor genes are also involved in controlling cell growth and division. Cells with certain alterations in tumor suppressor genes may divide in an uncontrolled manner.

DNA repair genes are involved in fixing damaged DNA. Cells with mutations in these genes tend to develop additional mutations in other genes and changes in their chromosomes, such as duplications and deletions of chromosome parts. Together, these mutations may cause the cells to become cancerous.

As scientists have learned more about the molecular changes that lead to cancer, they have found that certain mutations commonly occur in many types of cancer. Now there are many cancer treatments available that target gene mutations found in cancer. A few of these treatments can be used by anyone with a cancer that has the targeted mutation, no matter where the cancer started growing.

When Cancer Spreads


A cancer that has spread from the place where it first formed to another place in the body is called metastatic cancer. The process by which cancer cells spread to other parts of the body is called metastasis.

Metastatic cancer has the same name and the same type of cancer cells as the original, or primary, cancer. For example, breast cancer that forms a metastatic tumor in the lung is metastatic breast cancer, not lung cancer.

Under a microscope, metastatic cancer cells generally look the same as cells of the original cancer. Moreover, metastatic cancer cells and cells of the original cancer usually have some molecular features in common, such as the presence of specific chromosome changes.

In some cases, treatment may help prolong the lives of people with metastatic cancer. In other cases, the primary goal of treatment for metastatic cancer is to control the growth of the cancer or to relieve symptoms it is causing. Metastatic tumors can cause severe damage to how the body functions, and most people who die of cancer die of metastatic disease.

Tissue Changes that Are Not Cancer


Not every change in the body’s tissues is cancer. Some tissue changes may develop into cancer if they are not treated, however. Here are some examples of tissue changes that are not cancer but, in some cases, are monitored because they could become cancer:

  • Hyperplasia occurs when cells within a tissue multiply faster than normal and extra cells build up. However, the cells and the way the tissue is organized still look normal under a microscope. Hyperplasia can be caused by several factors or conditions, including chronic irritation.
  • Dysplasia is a more advanced condition than hyperplasia. In dysplasia, there is also a buildup of extra cells. But the cells look abnormal and there are changes in how the tissue is organized. In general, the more abnormal the cells and tissue look, the greater the chance that cancer will form. Some types of dysplasia may need to be monitored or treated, but others do not. An example of dysplasia is an abnormal mole (called a dysplastic nevus) that forms on the skin. A dysplastic nevus can turn into melanoma, although most do not.
  • Carcinoma in situ is an even more advanced condition. Although it is sometimes called stage 0 cancer, it is not cancer because the abnormal cells do not invade nearby tissue the way that cancer cells do. But because some carcinomas in situ may become cancer, they are usually treated.

Types of Cancer


There are more than 100 types of cancer. Types of cancer are usually named for the organs or tissues where the cancers form. For example, lung cancer starts in the lung, and brain cancer starts in the brain. Cancers also may be described by the type of cell that formed them, such as an epithelial cell or a squamous cell.

You can search NCI’s website for information on specific types of cancer based on the cancer’s location in the body

Here are some categories of cancers that begin in specific types of cells:

Carcinoma

Carcinomas are the most common type of cancer. They are formed by epithelial cells, which are the cells that cover the inside and outside surfaces of the body. There are many types of epithelial cells, which often have a column-like shape when viewed under a microscope.

Carcinomas that begin in different epithelial cell types have specific names:

Adenocarcinoma is a cancer that forms in epithelial cells that produce fluids or mucus. Tissues with this type of epithelial cell are sometimes called glandular tissues. Most cancers of the breast, colon, and prostate are adenocarcinomas.

Basal cell carcinoma is a cancer that begins in the lower or basal (base) layer of the epidermis, which is a person’s outer layer of skin.

Squamous cell carcinoma is a cancer that forms in squamous cells, which are epithelial cells that lie just beneath the outer surface of the skin. Squamous cells also line many other organs, including the stomach, intestines, lungs, bladder, and kidneys. Squamous cells look flat, like fish scales, when viewed under a microscope. Squamous cell carcinomas are sometimes called epidermoid carcinomas.

Transitional cell carcinoma is a cancer that forms in a type of epithelial tissue called transitional epithelium, or urothelium. This tissue, which is made up of many layers of epithelial cells that can get bigger and smaller, is found in the linings of the bladder, ureters, and part of the kidneys (renal pelvis), and a few other organs. Some cancers of the bladder, ureters, and kidneys are transitional cell carcinomas.

Sarcoma

Sarcomas are cancers that form in bone and soft tissues, including muscle, fat, blood vessels, lymph vessels, and fibrous tissue (such as tendons and ligaments).

Osteosarcoma is the most common cancer of bone. The most common types of soft tissue sarcoma are leiomyosarcoma, Kaposi sarcoma, malignant fibrous histiocytoma, liposarcoma, and dermatofibrosarcoma protuberans.

Leukemia

Cancers that begin in the blood-forming tissue of the bone marrow are called leukemias. These cancers do not form solid tumors. Instead, large numbers of abnormal white blood cells (leukemia cells and leukemic blast cells) build up in the blood and bone marrow, crowding out normal blood cells. The low level of normal blood cells can make it harder for the body to get oxygen to its tissues, control bleeding, or fight infections.

There are four common types of leukemia, which are grouped based on how quickly the disease gets worse (acute or chronic) and on the type of blood cell the cancer starts in (lymphoblastic or myeloid). Acute forms of leukemia grow quickly and chronic forms grow more slowly.

Lymphoma

Lymphoma is cancer that begins in lymphocytes (T cells or B cells). These are disease-fighting white blood cells that are part of the immune system. In lymphoma, abnormal lymphocytes build up in lymph nodes and lymph vessels, as well as in other organs of the body.

There are two main types of lymphoma:

Hodgkin lymphoma – People with this disease have abnormal lymphocytes that are called Reed-Sternberg cells. These cells usually form from B cells.

Non-Hodgkin lymphoma – This is a large group of cancers that start in lymphocytes. The cancers can grow quickly or slowly and can form from B cells or T cells.

Multiple Myeloma

Multiple myeloma is cancer that begins in plasma cells, another type of immune cell. The abnormal plasma cells, called myeloma cells, build up in the bone marrow and form tumors in bones all through the body. Multiple myeloma is also called plasma cell myeloma and Kahler disease.

Melanoma

Melanoma is cancer that begins in cells that become melanocytes, which are specialized cells that make melanin (the pigment that gives skin its color). Most melanomas form on the skin, but melanomas can also form in other pigmented tissues, such as the eye.

Brain and Spinal Cord Tumors

There are different types of brain and spinal cord tumors. These tumors are named based on the type of cell in which they formed and where the tumor first formed in the central nervous system. For example, an astrocytic tumor begins in star-shaped brain cells called astrocytes, which help keep nerve cells healthy. Brain tumors can be benign (not cancer) or malignant (cancer).

Other Types of Tumors


Germ Cell Tumors

Germ cell tumors are a type of tumor that begins in the cells that give rise to sperm or eggs. These tumors can occur almost anywhere in the body and can be either benign or malignant.

Neuroendocrine Tumors

Neuroendocrine tumors form from cells that release hormones into the blood in response to a signal from the nervous system. These tumors, which may make higher-than-normal amounts of hormones, can cause many different symptoms. Neuroendocrine tumors may be benign or malignant.

Carcinoid Tumors

Carcinoid tumors are a type of neuroendocrine tumor. They are slow-growing tumors that are usually found in the gastrointestinal system (most often in the rectum and small intestine). Carcinoid tumors may spread to the liver or other sites in the body, and they may secrete substances such as serotonin or prostaglandins, causing carcinoid syndrome.

Bronchoscopy

Bronchoscopy is a procedure that lets doctors look at your lungs and air passages. It’s usually performed by a doctor who specializes in lung disorders (a pulmonologist). During bronchoscopy, a thin tube (bronchoscope) is passed through your nose or mouth, down your throat and into your lungs.

Bronchoscopy is most commonly performed using a flexible bronchoscope. However, in certain situations, such as if there’s a lot of bleeding in your lungs or a large object is stuck in your airway, a rigid bronchoscope may be needed.

Common reasons for needing bronchoscopy are a persistent cough, infection or something unusual seen on a chest X-ray or other test.

Bronchoscopy can also be used to obtain samples of mucus or tissue, to remove foreign bodies or other blockages from the airways or lungs, or to provide treatment for lung problems.

What is bronchoscopy?


Bronchoscopy is a procedure to look directly at the airways in the lungs using a thin, lighted tube (bronchoscope). The bronchoscope is put in the nose or mouth. It is moved down the throat and windpipe (trachea), and into the airways. A healthcare provider can then see the voice box (larynx), trachea, large airways to the lungs (bronchi), and smaller branches of the bronchi (bronchioles).

There are 2 types of bronchoscopes: flexible and rigid. Both types come in different widths.

A rigid bronchoscope is a straight tube. It’s only used to view the larger airways. It may be used within the bronchi to:

  • Remove a large number of secretions or blood
  • Control bleeding
  • Remove foreign objects
  • Remove diseased tissue (lesions)
  • Do procedures, such as stents and other treatments

A flexible bronchoscope is used more often. Unlike the rigid scope, it can be moved down into the smaller airways (bronchioles). The flexible bronchoscope may be used to:

  • Place a breathing tube in the airway to help give oxygen
  • Suction out secretions
  • Take tissue samples (biopsy)
  • Put medicine into the lungs

Why might I need bronchoscopy?


A bronchoscopy may be done to diagnose and treat lung problems such as:

  • Tumors or bronchial cancer
  • Airway blockage (obstruction)
  • Narrowed areas in airways (strictures)
  • Inflammation and infections such as tuberculosis (TB), pneumonia, and fungal or parasitic lung infections
  • Interstitial pulmonary disease
  • Causes of persistent cough
  • Causes of coughing up blood
  • Spots seen on chest X-rays
  • Vocal cord paralysis

Diagnostic procedures or treatments that are done with bronchoscopy include:

  • Biopsy of tissue
  • Collection of sputum
  • Fluid put into the lungs and then removed (bronchoalveolar lavage or BAL) to diagnose lung disorders
  • Removal of secretions, blood, mucus plugs, or growths (polyps) to clear airways
  • Control of bleeding in the bronchi
  • Removing foreign objects or other blockages
  • Laser therapy or radiation treatment for bronchial tumors
  • Placement of a small tube (stent) to keep an airway open (stent placement)
  • Draining an area of pus (abscess)

Your healthcare provider may also have other reasons to advise a bronchoscopy.

How do I prepare for bronchoscopy?


Your healthcare providers will give you specific instructions about how to prepare.

You’ll need to fast (not eat or drink) for a certain period of time before the procedure. You may also have to stop taking certain medications that can thin your blood, like warfarin.

You will have a sedative or anesthesia before the procedure. You should plan on having someone available to drive you home afterward.

What happens during a bronchoscopy?


The entire bronchoscopy procedure typically takes from 30 minutes to a couple of hours. It’s usually performed in a hospital as an outpatient procedure. During a bronchoscopy:

  1. You lie on a bed or table with your head propped up.
  2. Your provider inserts an IV into your arm to deliver a sedative to help you relax. Some people may prefer to be asleep for the procedure. Rigid bronchoscopy and certain types of flexible bronchoscopy usually requires general anesthesia (being asleep). You and your provider can decide if general anesthesia is right for you.
  3. Your provider applies a numbing spray to your mouth (or nose) and throat.
  4. Once the area is numb and you are sedated, the provider inserts the bronchoscope through your nose or mouth and down into your windpipe to your lungs.
  5. After the procedure, the provider gently removes the bronchoscope. Your healthcare team monitors your condition until you are fully awake.

What happens after a bronchoscopy?


Bronchoscopy is an outpatient procedure, so you will not need to spend the night in the hospital. Patients can typically go home within a few hours of the procedure.

Your healthcare team will monitor you after the procedure to ensure you are breathing and swallowing properly. It will take a couple of hours for the numbness in your throat to wear off. You may have a sore throat, cough or hoarseness after the procedure for the next 24 hours.

Your healthcare team will let you know when you should expect test results and when you should schedule a follow-up appointment.

Advin Bronchoscopy products


Tuberculosis

TB is caused by bacteria (Mycobacterium tuberculosis) and it most often affects the lungs. TB is spread through the air when people with lung TB cough, sneeze or spit. A person needs to inhale only a few germs to become infected.

Every year, 10 million people fall ill with tuberculosis (TB). Despite being a preventable and curable disease, 1.5 million people die from TB each year – making it the world’s top infectious killer.

TB is the leading cause of death of people with HIV and also a major contributor to antimicrobial resistance.

Most of the people who fall ill with TB live in low- and middle-income countries, but TB is present all over the world. About half of all people with TB can be found in 8 countries: Bangladesh, China, India, Indonesia, Nigeria, Pakistan, Philippines and South Africa.

About one-quarter of the world’s population is estimated to be infected by TB bacteria. Only 5-15% of these people will fall ill with active TB disease. The rest have TB infection but are not ill and cannot transmit the disease. Both TB infection and disease are curable using antibiotics.

What IS TB?


Tuberculosis (TB) is a bacterial disease that usually attacks the lungs. But it can also attack other parts of the body, including the kidneys, spine, and brain.

Not everyone infected with TB bacteria (germs) becomes sick. So, there are two types of TB conditions:

  • Latent TB infection, where the TB germs live in your body but don’t make you sick.
  • TB disease (active TB) where you get sick from the TB germs. TB disease can almost always be cured with antibiotics. But if it’s not treated properly, it can be fatal.

What causes tuberculosis (TB)?


TB is caused by bacteria (germs) called Mycobacterium tuberculosis. The germs spread from person to person through the air. People who have TB disease in their throat or lungs spread the germs in the air when they cough, sneeze, talk, or sing. If you breathe in the air that has the germs, you can get TB. TB is not spread by touching, kissing, or sharing food or dishes.

You’re more likely to catch TB from people you live or work with than from people you see for shorter amounts of time.

Although tuberculosis is contagious, it’s not easy to catch. You’re much more likely to get tuberculosis from someone you live or work with than from a stranger. Most people with active TB who’ve had appropriate drug treatment for at least two weeks are no longer contagious.

HIV and TB


Since the 1980s, tuberculosis cases have increased dramatically because of the spread of HIV, the virus that causes AIDS. HIV suppresses the immune system, making it difficult for the body to control TB bacteria. As a result, people with HIV are much more likely to get TB and to progress from latent to active disease than are people who aren’t HIV positive.

Drug-resistant TB


Tuberculosis also remains a major killer because of the increase in drug-resistant strains. Over time, some TB germs have developed the ability to survive despite medications. This is partly because people don’t take their drugs as directed or don’t complete the course of treatment.

Drug-resistant strains of tuberculosis emerge when an antibiotic fails to kill all of the bacteria it targets. The surviving bacteria become resistant to that drug and often other antibiotics as well. Some TB bacteria have developed resistance to the most commonly used treatments, such as isoniazid and rifampin (Rifadin, Rimactane).

Some TB strains have also developed resistance to drugs less commonly used in TB treatment, such as the antibiotics known as fluoroquinolones, and injectable medications including amikacin and capreomycin (Capastat). These medications are often used to treat infections that are resistant to the more commonly used drugs.

What are the symptoms of tuberculosis (TB)?


Most people who have TB germs in their bodies don’t get sick with TB disease. Instead, they have latent TB infection. With a latent TB infection, you:

  • Don’t have symptoms
  • Can’t spread TB to others
  • Could get sick with active TB disease in the future if your immune system becomes weak for another reason
  • Need to take medicine to prevent getting sick with active TB disease in the future

If you have TB disease, the TB germs are active, meaning that they are growing (multiplying) inside your body and making you sick. If the TB is growing in your lungs or throat, you can spread the TB germs to other people. You can get sick with TB disease weeks to years after you’re infected with TB germs.

With TB disease, your symptoms will depend on where the TB is growing in your body

General symptoms may include:

  • Chills and fever
  • Night sweats (heavy sweating during sleep)
  • Losing weight without trying
  • Loss of appetite
  • Weakness or fatigue

Symptoms from TB disease in your lungs may include:

  • A coughthat lasts longer than 3 weeks
  • Coughing up blood or sputum (a thick mucus from the lungs)
  • Chest pain

What is the treatment for tuberculosis (TB)?


The treatment for both latent TB infection and TB disease is antibiotics. To make sure you get rid of all the TB germs in your body, it’s very important to follow the directions for taking your medicine.

If you don’t follow the directions, the TB germs in your body could change and become antibiotic resistant. That means the medicine may stop working and your TB may become hard to cure.

  • For latent TB infections, you usually take medicines for 3 to 9 months. Treatment helps make sure you don’t get TB disease in the future.
  • For active TB disease, you usually need to take medicines for 6 to 12 months. Treatment will almost always cure you if you take your pills the right way.
  • For TB disease in your lungs or throat, you’ll need to stay home for a few weeks, so you don’t spread disease to other people.

You can protect the people you live with by:

  • Covering your nose and mouth.
  • Opening windows when possible.
  • Not getting too close to them.

Blood Cancer

Your blood, which accounts for about 8 percent of your normal body weight, plays an important role in how your body functions. As your blood circulates throughout your vascular system, it supplies all of your organs with oxygen, nutrients, hormones and antibodies. Blood is made of an almost equal mix of plasma (the liquid that transports cells, waste and nutrients, among other things) and blood cells (red blood cells, white blood cells and platelets).

When cancer occurs in the blood, it’s usually the result of an abnormal and excessive reproduction of white blood cells. Blood cancers account for about 10 percent of all diagnosed cancers in the U.S. each year. Blood cancers (including leukemia, lymphoma and myeloma) are more common in men than women. Childhood leukemia accounts for about 25 percent of all cancers in children.

Treatments for blood cancers also vary, ranging from active surveillance without cancer-directed therapy to standard cancer treatments including immunotherapies, chemotherapies and targeted agents. “With over 100 different types of blood cancers now recognized, it is important to have an accurate diagnosis prior to deciding on treatment

What is Blood ?


Your blood is made up of liquid and solids. The liquid part, called plasma, is made of water, salts, and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells, and platelets.

Red blood cells (RBC) deliver oxygen from your lungs to your tissues and organs. White blood cells (WBC) fight infection and are part of your immune system. Platelets help blood to clot when you have a cut or wound. Bone marrow, the spongy material inside your bones, makes new blood cells. Blood cells constantly die and your body makes new ones. Red blood cells live about 120 days, and platelets live about 6 days. Some white blood cells live less than a day, but others live much longer.

There are four blood types: A, B, AB, or O. Also, blood is either Rh-positive or Rh-negative. So if you have type A blood, it’s either A positive or A negative. Which type you are is important if you need a blood transfusion. And your Rh factor could be important if you become pregnant – an incompatibility between your type and the baby’s could create problems.

Types of blood cancer


The three main types of blood and bone marrow cancer are leukemia, lymphoma and myeloma:

  • Leukemia is a blood cancer that originates in the blood and bone marrow. It occurs when the body creates too many abnormal white blood cells and interferes with the bone marrow’s ability to make red blood cells and platelets.
  • Non-Hodgkin lymphoma is a blood cancer that develops in the lymphatic system from cells called lymphocytes, a type of white blood cell that helps the body fight infections.
  • Hodgkin lymphoma is a blood cancer that develops in the lymphatic system from cells called lymphocytes. Hodgkin lymphoma is characterized by the presence of an abnormal lymphocyte called the Reed-Sternberg cell.
  • Multiple myeloma is a blood cancer that begins in the blood’s plasma cells, a type of white blood cell made in the bone marrow. Also, learn about the stages of multiple myeloma.

There are also less common forms of blood and bone marrow cancers, or associated disorders, including:

  • Myelodysplastic syndromes (MDS): These are rare conditions that may result from damage to blood-forming cells in the bone marrow.
  • Myeloproliferative neoplasms (MPNs): These rare blood cancers occur when the body overproduces white blood cells, red blood cells or platelets. The three main subcategories are essential thrombocythemia (ET), myelofibrosis (MF) and polycythemia vera (PV).
  • Amyloidosis: This rare disorder, characterized by the buildup of an abnormal protein called amyloid, is not a form of cancer. But it is closely associated with multiple myeloma.
  • Waldenstrom macroglobulinemia: This is a rare type of non-Hodgkin lymphoma that starts in B cells.
  • Aplastic anemia: This rare condition occurs when key stem cells are damaged and can only be treated with a bone marrow transplant.

Blood cancer symptoms


Some common bone marrow and blood cancer symptoms include:

  • Fever, chills
  • Persistent fatigue, weakness
  • Loss of appetite, nausea
  • Unexplained weight loss
  • Night sweats
  • Bone/joint pain
  • Abdominal discomfort
  • Headaches
  • Shortness of breath
  • Frequent infections
  • Itchy skin or skin rash
  • Swollen lymph nodes in the neck, underarms or groin

Who is at risk for blood cancer?


The risk factors for blood cancer are not fully understood, though it is believed that blood cancers develop from a combination of genetic and environmental factors. Smoking, radiation exposure, and exposure to certain chemicals have all been linked to increased risk of some types of blood cancers. Epstein-Barr virus, HIV and human T-cell lymphoma/leukemia virus infections are also risk factors for developing lymphomas and leukemias.

How is blood cancer diagnosed?


  • Leukemia: Your doctor will obtain a complete blood count (CBC) test, which can identify abnormal levels of white blood cells relative to red blood cells and platelets.
  • Lymphoma: Your doctor will need to perform a biopsy, which removes a small portion of tissue to be examined under a microscope. In some cases, your doctor may also order an X-ray, CT or PET scan to detect swollen lymph nodes.
  • Myeloma: Your doctor will order a CBC, or other blood or urine tests to detect chemicals or proteins produced as a function of myeloma development. In some cases, bone marrow biopsy, X-ray, MRI, PET, and CT scans can be used to confirm the presence and extent of the spread of myeloma.

What are the treatments for blood cancer?


Treatment will depend on several factors. These include the type of blood cancer you have, your age, how fast the cancer is progressing, and whether the cancer has spread to other parts of your body.

Because treatments for blood cancer have vastly improved over the last several decades, many types of blood cancers are now highly treatable. Common treatments include the following:

  • Chemotherapy: Anticancer drugs are introduced to the body (via injection into the vein or sometimes by taking a pill) to kill and halt the production of cancer cells.
  • Radiation therapy: This form of cancer treatment uses high-energy rays to kill cancer cells.
  • Targeted therapies: This form of cancer treatment uses drugs that specifically kill malignant blood cells, without harming normal cells. Targeted therapies are most commonly used to treat leukemia.
  • Stem cell transplantation: Healthy stem cells can be infused into your body to help resume healthy blood production following therapy to destroy malignant blood cells.
  • Cancer Surgery: This treatment involves removing the affected lymph nodes to treat some lymphomas.
  • Immunotherapy: This treatment activates the immune system to specifically kill cancer cells.

Blood cancer treatment and therapy options


Treatment for blood and bone marrow cancers depends on the type of cancer, your age, how fast the cancer is progressing, where the cancer has spread and other factors. Some common blood cancer treatments for leukemia, lymphoma, and multiple myeloma include:

Stem cell transplantation: A stem cell transplant infuses healthy blood-forming stem cells into the body. Stem cells may be collected from the bone marrow, circulating blood and umbilical cord blood.

Chemotherapy: Chemotherapy uses anticancer drugs to interfere with and stop the growth of cancer cells in the body. Chemotherapy for blood cancer sometimes involves giving several drugs together in a set regimen. This treatment may also be given before a stem cell transplant.

Radiation therapy: Radiation therapy may be used to destroy cancer cells or to relieve pain or discomfort. It may also be given before a stem cell transplant.

Diabetes

What is Diabetes?


Diabetes is a chronic (long-lasting) health condition that affects how your body turns food into energy.

Your body breaks down most of the food you eat into sugar (glucose) and releases it into your bloodstream. When your blood sugar goes up, it signals your pancreas to release insulin. Insulin acts like a key to let the blood sugar into your body’s cells for use as energy.

With diabetes, your body doesn’t make enough insulin or can’t use it as well as it should. When there isn’t enough insulin or cells stop responding to insulin, too much blood sugar stays in your bloodstream. Over time, that can cause serious health problems, such as heart disease, vision loss, and kidney disease.

What are the different types of diabetes?


Type 1 diabetes

If you have type 1 diabetes, your body does not make insulin. Your immune system attacks and destroys the cells in your pancreas that make insulin. Type 1 diabetes is usually diagnosed in children and young adults, although it can appear at any age. People with type 1 diabetes need to take insulin every day to stay alive.

Type 2 Diabetes

With type 2 diabetes, your body doesn’t use insulin well and can’t keep blood sugar at normal levels. About 90-95% of people with diabetes have type 2. It develops over many years and is usually diagnosed in adults (but more and more in children, teens, and young adults). You may not notice any symptoms, so it’s important to get your blood sugar tested if you’re at risk. Type 2 diabetes can be prevented or delayed with healthy lifestyle changes,

Gestational Diabetes

Gestational diabetes develops in pregnant women who have never had diabetes. If you have gestational diabetes, your baby could be at higher risk for health problems. Gestational diabetes usually goes away after your baby is born. However, it increases your risk for type 2 diabetes later in life. Your baby is more likely to have obesity as a child or teen and develop type 2 diabetes later in life.

How common is diabetes?


As of 2015, 30.3 million people in the United States, or 9.4 percent of the population, had diabetes. More than 1 in 4 of them didn’t know they had the disease. Diabetes affects 1 in 4 people over the age of 65. About 90-95 percent of cases in adults are type 2 diabetes.1

Who is more likely to develop type 2 diabetes?


You are more likely to develop type 2 diabetes if you are age 45 or older, have a family history of diabetes, or are overweight. Physical inactivity, race, and certain health problems such as high blood pressure also affect your chance of developing type 2 diabetes. You are also more likely to develop type 2 diabetes if you have prediabetes or had gestational diabetes when you were pregnant. Learn more about risk factors for type 2 diabetes.

Symptoms


 

Diabetes symptoms depend on how high your blood sugar is. Some people, especially if they have prediabetes or type 2 diabetes, may not have symptoms. In type 1 diabetes, symptoms tend to come on quickly and be more severe.

Some of the symptoms of type 1 diabetes and type 2 diabetes are:

  • Feeling more thirsty than usual.
  • Urinating often.
  • Losing weight without trying.
  • Presence of ketones in the urine. Ketones are a byproduct of the breakdown of muscle and fat that happens when there’s not enough available insulin.
  • Feeling tired and weak.
  • Feeling irritable or having other mood changes.
  • Having blurry vision.
  • Having slow-healing sores.
  • Getting a lot of infections, such as gum, skin and vaginal infections.

Internet of Things (IoT) Used In Heath Care

What is the Internet of Things (IoT)?


The internet of things (IoT) is a catch-all term for the growing number of electronics that aren’t traditional computing devices, but are connected to the internet to send data, receive instructions or both.

There’s an incredibly broad range of ‘things’ that fall under the IoT umbrella: Internet-connected ‘smart’ versions of traditional appliances such as refrigerators and light bulbs; gadgets that could only exist in an internet-enabled world such as Alexa-style digital assistants; and internet-enabled sensors that are transforming factories, healthcare, transportation, distribution centers and farms.

The term IoT, or Internet of Things, refers to the collective network of connected devices and the technology that facilitates communication between devices and the cloud, as well as between the devices themselves. Thanks to the advent of inexpensive computer chips and high bandwidth telecommunication, we now have billions of devices connected to the internet. This means everyday devices like toothbrushes, vacuums, cars, and machines can use sensors to collect data and respond intelligently to users.

The Internet of Things integrates everyday “things” with the internet. Computer Engineers have been adding sensors and processors to everyday objects since the 90s. However, progress was initially slow because the chips were big and bulky. Low power computer chips called RFID tags were first used to track expensive equipment. As computing devices shrank in size, these chips also became smaller, faster, and smarter over time.

How does the IoT work?


The first element of an IoT system is the device that gathers data. Broadly speaking, these are internet-connected devices, so they each have an IP address. They range in complexity from autonomous mobile robots and forklifts that move products around factory floors and warehouses, to simple sensors that monitor the temperature or scan for gas leaks in buildings.

They also include personal devices such as fitness trackers that monitor the number of steps individuals take each day.

In the next step in the IoT process, collected data is transmitted from the devices to a gathering point. Moving the data can be done wirelessly using a range of technologies or over wired networks. Data can be sent over the internet to a data center or the cloud. Or the transfer can be performed in phases, with intermediary devices aggregating the data, formatting it, filtering it, discarding irrelevant or duplicative data, then sending the important data along for further analysis.

The final step, data processing and analytics, can take place in data centres or the cloud, but sometimes that’s not an option. In the case of critical devices such as shutoffs in industrial settings, the delay of sending data from the device to a remote data centre is too great. The round-trip time for sending data, processing it, analysing it and returning instructions (close that valve before the pipes burst) can take too long.

In such cases edge computing can come into play, where a smart edge device can aggregate data, analyse it and fashion responses, if necessary, all within relatively close physical distance, thereby reducing delay. Edge devices also have upstream connectivity for sending data to be further processed and stored.

A growing number of edge computing use cases, such as autonomous vehicles that need to make split-second decisions, is accelerating the development of edge technologies that can process and analyse data immediately without going to the cloud.

Why Healthcare Needs IoT?


To Enhance Patient Satisfaction & Engagement: IoT can increase patient satisfaction by optimizing surgical workflow. E.g., informing about patient’s discharge from surgery to their families. It can increase patient engagement by allowing patients to spend more time interacting with their physicians as it reduces the need for direct patient-physician interaction as devices connected to the internet are delivering valuable data.

To Advance Population Health Management: IoT enables providers to integrate devices to observe the growth of wearables as data captured by the device will fill in the data that is otherwise missed out in EHR. Care teams can receive insight driven prioritization and use IoT for home monitoring of chronic diseases. This is another way that caregivers can make their presence felt in daily lives of the patients.

To Promote Preventive Care: Prevention has become a primary area of focus as health care expenses are projected to grow unmanageable in the future. The widespread access to real-time, high fidelity data on each individual’s health will reform health care by helping people live healthier lives and prevent disease.

To Advance Care Management: It can enable care teams to collect and connect millions of data points on personal fitness from wearables like heart-rate, sleep, perspiration, temperature, and activity. Consequently, sensor-fed information can send out alerts to patients and caregivers in real-time so they get event-triggered messaging like alerts and triggers for elevated heart-rate etc. This will not just massively improve workflow optimization but also, ensure that all care is managed from the comfort of home.

To Improve Patient Health: What if the wearable device connected to a patient tells you when his heart-rate is going haywire or if he has lagged behind in taking good care of himself and shared that information on other devices that you used while working? By updating personal health data of patients on the cloud and eliminating the need to feed it into the EMRs, IoT ensures that every tiny detail is taken into consideration to make the most advantageous decisions for patients. Moreover, it can be used as a medical adherence and home monitoring tool.

To Turn Data Into Actions: Quantified health is going to be future of healthcare because health that is measurable can be better improved. Therefore, it is wise to take advantage of quantified health technology. We also know that data affects performance so, an object measurement and tracking of health for better outcomes is why we need IoT.

IoT for Hospitals


Apart from monitoring patients’ health, there are many other areas where IoT devices are very useful in hospitals. IoT devices tagged with sensors are used for tracking real time location of medical equipment like wheelchairs, defibrillators, nebulizers, oxygen pumps and other monitoring equipment. Deployment of medical staff at different locations can also be analyzed real time.

The spread of infections is a major concern for patients in hospitals. IoT-enabled hygiene monitoring devices help in preventing patients from getting infected. IoT devices also help in asset management like pharmacy inventory control, and environmental monitoring, for instance, checking refrigerator temperature, and humidity and temperature control.

IoT for Health Insurance Companies


There are numerous opportunities for health insurers with IoT-connected intelligent devices. Insurance companies can leverage data captured through health monitoring devices for their underwriting and claims operations. This data will enable them to detect fraud claims and identify prospects for underwriting. IoT devices bring transparency between insurers and customers in the underwriting, pricing, claims handling, and risk assessment processes. In the light of IoT-captured data-driven decisions in all operation processes, customers will have adequate visibility into underlying thought behind every decision made and process outcomes.

Insurers may offer incentives to their customers for using and sharing health data generated by IoT devices. They can reward customers for using IoT devices to keep track of their routine activities and adherence to treatment plans and precautionary health measures. This will help insurers to reduce claims significantly. IoT devices can also enable insurance companies to validate claims through the data captured by these devices.

Benefits in health care


Simultaneous reporting and monitoring

Remote health monitoring monitoring via connected devices can save lives in event of a medical emergency like heart failure, diabetes, asthma attacks, etc.

With real-time monitoring of the health condition in place by means of a smart medical device connected to a smartphone app, connected medical devices can collect medical and other required health data and use the data connection of the smartphone to transfer collected information to a physician or to a cloud platform.

Center of Connected Health Policy conducted a study that indicates that there was a 50% reduction in 30-day readmission rate because of remote patient monitoring on heart failure patients.

The IoT device collects and transfers health data: blood pressure, oxygen and blood sugar levels, weight, and ECGs.

These data are stored in the cloud and can be shared with an authorized person, who could be a physician, your insurance company, a participating health firm or an external consultant, to allow them to look at the collected data regardless of their place, time, or device.

End-to-end connectivity and affordability

IoT can automate patient care workflow with the help healthcare mobility solution and other new IoT technologies, and next-gen healthcare facilities.

IoT in healthcare enables interoperability, artificial intelligence machine-to-machine communication, information exchange, and data movement that makes healthcare service delivery effective.

Connectivity protocols: Bluetooth LE, Wi-Fi, Z-wave, ZigBee, and other modern protocols, healthcare personnel can change the way they spot illness and ailments in patients and can also innovate revolutionary ways of treating across different healthcare fields.

Consequently, technology-driven setup brings down the healthcare cost, by cutting down unnecessary visits, utilizing better quality resources, and improving the allocation and planning.

Data assortment and analysis

Vast amount of data that a healthcare device sends in a very short time owing to their real-time application is hard to store and manage if the access to cloud is unavailable.

Even for healthcare professionals to acquire data originating from multiple devices and sources and analyze it manually is a tough bet.

IoT devices can collect, report and analyses the real time information and cut the need to store the raw data.

This all can happen overcloud with the providers only getting access to final reports with graphs.

Moreover, healthcare operations allow organizations to get vital healthcare analytics and data-driven insights which speed up decision-making and is less prone to errors.

Tracking and alerts

On-time alert is critical in chronic condition. Medical IoT devices gather vital signs of any disease and transfer that data to doctors for real-time tracking, while dropping notifications to people about critical parts via mobile apps and smart sensors.

Reports and alerts give a firm opinion about a patient’s condition, irrespective of place and time.

It also helps healthcare providers to make well-versed decisions and provide on-time treatment.

Thus, IoT enables real-time alerting, tracking, and monitoring, which permits hands-on treatments, better accuracy, apt intervention by doctors and improve complete patient care delivery results.

Remote medical assistance

In event of an emergency, patients can contact a doctor who is many kilometers away with a smart mobile apps.

With mobility solutions in healthcare, the medics can instantly check the patients and identify the ailments on-the-go.

Also, numerous IoT-based healthcare delivery chains that are forecasting to build machines that can distribute drugs on the basis of patient’s prescription and ailment-related data available via linked devices.

IoT will Improve the patient’s care In hospital. This in turn, will cut on people’s expense on healthcare